Study of the function of Thyroid gland in β- thalassemia major male patients in Kirkuk city.

Mossa M. Marbut; Bassam Saleh Jameel; Amina H. Hamed; Issa H. Kareem

Mossa M. Marbut Department of Physiology, College of Medicine, University of Tikrit.
Bassam Saleh Jameel Department of Physiology, College of Medicine, University of Tikrit.
Amina H. Hamed
Issa H. Kareem The thalassaemia center in Azadi Teaching hospital, Kirkuk.

Keywords: PCV, Hb, Weight, height, thyroid gland, T3, T4, male, Thalassemia, Kirkuk, Iraq.

Abstract

Thalassemia has been classified by the world health organization as a major public health problem. It
occurs throughout the world and regarded as one of the major health problems in endemic regions
as Middle East, Mediterranean countries, Asia and North Africa. Endocrine complications in
Thalassaemia Major Patients with multitransfused Thalassaemia Major patients may develop severe
endocrine complications. Due to multiple transfusions is the main cause of such complications, Iron
accumulates in many tissues such as liver, heart and endocrine glands. The study aims to study the
function of Thyroid gland in β- thalassemia Major male patients in Kirkuk city. The study was
conducted β-thalassaemia major patients whom attended the thalassaemia center in Azadi Teaching
hospital in Kirkuk Governorate from September 2015 to the end of January 2016. A total of 105 male
subjects were participated in the study, (30 normal healthy subjects and 75 thalassaemic patients).
Body weight height was measured. About, five ml of venous blood were obtained from all normal
subjects and patients. One ml of blood sample was collected for measurement of packet cell volume
(PCV) and heamoglobin (Hb). The remaining four ml of blood sample were used for serum
separation. Serum used for measurement of serum thyroid stimulating hormones (TSH), T3 and T4.
Results of study showed a high significant decrease in body weight and height of male thalassemic
patients as compare with male counterpart of control subjects of same age. Also, there was a highly
significant reduction in the concentration of heamoglobin and PCV value in thalassaemic male
patients as compared with control male subjects. There is no significant increase in serum Thyroid
stimulating hormone (TSH) concentration in male thalassemic patients as compare with male control
subjects. However, there is highly significant reduction in serum T4 and T3 concentrations in male
thalassemic patients as compare with male control subjects.