Effect of Purified 1-Hydroxyphenazine Pigment on B rosette formation against Secondary hydatidosis
Abstract
The effect of purified 1-hydroxyphenazine pigment which was generated from Pseudomonas aeruginosa on specific immune response B cells inside the body of white BALB/C mice against experimental secondary hydatidosis and the infectivity of protoscoleces was studied. In comparison with negative control mice groups (P.B.S.) the results showed that the higher purified concentrations (100) mole/ml of this pigment had suppressive effect on this specific immune response B cells(B-Rosette formation) and this effect was highly significant after (6) weeks from challenge dose with protoscoleces intraperitoneally (I.P) against this pigment, and this effect reflects the protoscoleces infectivity which increased due to suppression of B rosette formation while the mitogen Phytohaemagglutinin (PHA) showed a significant stimulation of this specific humoral response which leads to decrement in protoscoleces infectivity in comparison with higher pigment concentrations .
